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Dipmed can trace its origins back to the ancient “Schola Medica Salernitana”, the first and most important medical institution in Medieval Europe and considered by many as the forerunner of modern medical schools. It flourished between 900 and 1300 AD, combining the Greek and Latin traditions with notions from Arabic and Jewish cultures. In 1811, its status was downgraded by King Joachim Murat, whose reorganization of the Kingdom granted the exclusive right to award degrees to the Federico II University in Naples.
The cornerstones of the Salerno Medical School's teachings were:

• The balance between SOMA and PSYCHE.

• Attention to NUTRITION in the treatment of illness and disease.

Dipmed was established as a Department of the University of Salerno by Rectoral Decree No. 2491 of 31 October 2012. Then, on 31 January 2013, the President of the Council of Ministers of the Italian Republic, Mr. Mario Monti, signed the decree establishing the "San Giovanni di Dio e Ruggi d'Aragona - Scuola Medica Salernitana" University Hospital (AOU), which is now an integral part of the University of Salerno and contributes to the achievement of the Department's teaching and research objectives.
The integration of research, teaching and healthcare makes the Department a national teaching centre with the highest medical speciality, providing comprehensive professional training to meet the multiple health needs of the area. One of Italy’s foremost high-speciality health authorities, the AOU comprises four hospital complexes: the San Giovanni di Dio e Ruggi d'Aragona and Giovanni da Procida Hospital in Salerno, the "Fucito" hospital in Mercato San Severino and the hospitals in Cava dei Tirreni and Castiglione di Ravello. These four hospitals are strategically located in the Salerno area and are highly integrated in order to cover local health needs. The polarization of the different clinical skills (medical, surgical, diagnostic and service) in the four structures and their close operational integration constitute a unique resource among regional health authorities. The company act establishing the Integrated Healthcare Department (DAI) is an operational model capable of ensuring the integrated exercise of healthcare, teaching and research activities. The DAI is a significant strength for the Department’s development as it represents the operational structure in which the resources offered by the research and training projects of university teaching and research staff are fully implemented for the benefit of the public health service.